Compositions and methods for treating, including preventing, parvovirus infections and related diseases

A method for treating an animal for a parvovirus infection, a disease related to a parvovirus infection, an erythrovirus infection, a disease related to an erythrovirus infection, a parvovirus B19 infection, or a disease related to a parvovirus B19 infection, comprising one or more administrations of one or more compositions comprising an mVLP comprising a polypeptide,

• wherein
• the compositions may be the same or different if there is more than one administration,
• the polypeptide comprises a VP2 polypeptide with at least one amino acid modification relative to a wild type VP2
• the wild type VP2 has the amino acid sequence of SEQ ID NO:
• 1 and
• the at least one amino acid modification comprises a substitution at Y401, a substitution at Q399, a substitution at Q400, a substitution at Q404, a substitution at Q368, a substitution at Q369, a substitution at Y392, Y401F, Y401W, Y401A, Q368A, Q369A, Q368N, Q369N, Q399N, Q400N, Q404T, Y392A, Y392F, Q404N, Y401P, T402A, D403A, Q404A, or combinations thereof.

A method for vaccinating an animal against a parvovirus infection, an erythrovirus infection, or a parvovirus B19 infection, comprising one or more administrations of one or more compositions comprising an mVLP comprising a polypeptide,

• wherein
• the compositions may be the same or different if there is more than one administration,
• the polypeptide comprises a VP2 polypeptide with at least one amino acid modification relative to a wild type VP2
• the wild type VP2 has the amino acid sequence of SEQ ID NO:
• 1 and
• the at least one amino acid modification comprises a substitution at Y401, a substitution at Q399, a substitution at Q400, a substitution at Q404, a substitution at Q368, a substitution at Q369, a substitution at Y392, Y401F, Y401W, Y401A, Q368A, Q369A, Q368N, Q369N, Q399N, Q400N, Q404T, Y392A, Y392F, Q404N, Y401P, T402A, D403A, Q404A, or combinations thereof.