Biaryl compounds as antimicrobial and chemotherapeutic agents

A compound of the formula:

• wherein:
• X1 is amino or alkylamino(C≤8), dialkylamino(C≤8), amido(C≤8), or a substituted version of any of these groups;
• or —N(Ra)Rb, wherein:
• Ra is a monovalent amino protecting group or is taken together with Rb and form a divalent amino protecting group;
• and
• Rb is hydrogen, a monovalent amino protecting group;
• or is taken together with Ra and form a divalent amino protecting group;
• X2 is hydroxy or alkoxy(C≤8), acyloxy(C≤8), or a substituted version of any of these groups;
• or —ORc wherein:
• Rc is a hydroxy protecting group;
• Y1 is halo;
• Y2 is hydrogen or halo;
• A1 and A2 are each independently hydrogen, halo, alkyl(C≤8), substituted alkyl(C≤8), cycloalkyl(C≤8), substituted cycloalkyl(C≤8), alkoxy(C≤8), or substituted alkoxy(C≤8);
• R1 and R2 are each independently hydrogen, halo, alkyl(C≤8), substituted alkyl(C≤8), cycloalkyl(C≤8), substituted cycloalkyl(C≤8), alkoxy(C≤8), or substituted alkoxy(C≤8);
• or R1 and R2 are taken together and are alkenediyl(C≤8) or substituted alkenediyl(C≤8);
• and
• R3 and R4 are each independently hydrogen, halo, alkyl(C≤8), substituted alkyl(C≤8), cycloalkyl(C≤8), substituted cycloalkyl(C≤8), alkoxy(C≤8), or substituted alkoxy(C≤8);
• or R3 and R4 are taken together and are alkenediyl(C≤8) or substituted alkenediyl(C≤8);
• or
• a compound of the formula:
• wherein:
• X3 is —ORd or —NReRf, wherein:
• Rd is hydrogen, alkyl(C≤8), cycloalkyl(C≤8), acyl(C≤8), or a substituted version of any of these groups;
• or a hydroxy protecting group;
• Re and Rf are each independently hydrogen, alkyl(C≤8), cycloalkyl(C≤8), acyl(C≤8), or a substituted version of any of these groups;
• or a monovalent amino protecting group, or Re and Rf are taken together and are a divalent amino protecting group;
• R6 is hydrogen or alkyl(C≤8), cycloalkyl(C≤8), or a substituted version of either of these groups;
• R7, R8, and R9 are each independently hydrogen, halo, or alkyl(C≤8), cycloalkyl(C≤8), alkoxy(C≤8), or a substituted version of any of these groups;
• or R7 and R8 are taken together and are alkenediyl(C≤8) or substituted alkenediyl(C≤8);
• and
• Y3, Y4, Y5, and Y6 are each independently hydrogen, halo, hydroxy, or alkyl(C≤8), cycloalkyl(C≤8), alkoxy(C≤8), or a substituted version of any of these groups;
• or Y3 and Y4 are taken together and are alkenediyl(C≤8) or substituted alkenediyl(C≤8), or Y4 and Y5 are taken together and are alkenediyl(C≤8) or substituted alkenediyl(C≤8), or Y5 and Y6 are taken together and are alkenediyl(C≤8) or substituted alkenediyl(C≤8);
• or a pharmaceutically acceptable salt thereof.