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US 2019/0201549 A1Published application
Novel drug delivery system based on jcv-vlp
AssigneeLife Science Inkubator Betriebs GmbH & Co. KG
InventorsVictoria Demina, Heiko Manninga, Armin Götzke, Alexander Glassmann
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Abstract
The invention relates to VLP derived from human polyoma virus loaded with a drug (cargo) as a drug delivery system for transporting said drug into the CNS, in particular of living humans.
Claims12
A method of treating a subject having a central nervous system (CNS) disease or a neurological, neuronal or neurodegenerative disorder, the method comprising:
- intravenously administering a drug delivery system composed of VLP loaded with a drug into a subject,
- wherein,
- the VLP crosses the blood-brain barrier (BBB) of the subject together with the drug,
- the VLP are composed of VP1 comprising an amino acid sequence which is at least 80% identical to the amino acid sequence according to SEQ ID NO:
- 1 over its entire length, and
- the drug delivery system is provided without the use of additives.
3 more elements
Dependencies are inferred from the claim text.