Systems and methods for optimization of bolus timing relative to meal events

A device for optimizing a timing of a short acting insulin medicament dosage in a prescribed insulin regimen for a subject, wherein the device comprises one or more processors and a memory, the memory comprising:

• instructions that, when executed by the one or more processors, perform a method of:
• obtaining a first data set, the first data set comprising a plurality of autonomous glucose measurements of the subject taken over a time course and, for each respective glucose measurement in the plurality of glucose measurements, a corresponding timestamp representing when in the time course the respective glucose measurement was made;
• identifying a plurality of meal events in the first data set that occurred during the time course;
• obtaining a second data set that specifies, for each respective meal event in the plurality of meal events, when a short acting insulin medicament dosage was injected by the subject relative to an occurrence of the respective meal event;
• segmenting the first data set into a plurality of segments, wherein each segment comprises glucose measurements that are associated with a period related to a meal event of the plurality of meal events;
• binning the plurality of segments of the first data set into a plurality of bins using the second data set, wherein each segment, associated with a respective meal event, is binned by determining when the short acting insulin medicament dosage was injected by the subject relative to the occurrence of the respective meal event, wherein each respective bin in the plurality of bins is associated with a relative time interval in a plurality of relative time intervals,
• each respective relative time interval in the plurality of relative time intervals defines a different time range for when the short acting insulin medicament dosage was injected by the subject relative to the occurrence of the meal event, and
• each respective bin is assigned glucose measurements in the plurality of glucose measurements that are associated with one or more periods within the time course in which the subject took the short acting insulin medicament dosage within the relative time interval associated with the respective bin;
• determining a first glycaemic risk measure for each respective bin in the plurality of bins using the autonomous glucose measurements assigned to the respective bin, thereby forming a plurality of first glycaemic risk measures;
• identifying an optimal relative time interval for the subject, from among the plurality of relative time intervals associated with the plurality of bins, for injecting the short acting insulin medicament dosage for a prospective meal event using the plurality of first glycaemic risk measures;
• and
• communicating the optimal relative time interval to a health care practitioner associated with the subject or directly to the subject.