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US 2019/0195884 A1Published application
Systems, apparatuses and methods for reading an amino acid sequence
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsStuart LINDSAY, Peiming ZHANG, Yanan ZHAO
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Abstract
Embodiments of the present disclosure relate to amino acid, modified amino acid, peptide and protein identification and sequencing, by means of, for example, electronic detection of individual amino acids or small peptides.
Claims16
An apparatus for sequencing and/or identifying at least one of protein, peptide, amino acid and/or modified amino acid, the apparatus comprising:
- a plurality of electrodes;
- at least a first electrode of the plurality of the electrodes being functionalized with a molecule strongly bonded to at least the first electrode and that forms transient bonds with an amino acid;
- voltage bias means for applying a voltage between the first electrode and a second electrode of the plurality of electrodes, wherein the first and second electrodes are arranged such that a gap is produced between them;
- and
- current data monitoring means for monitoring current passing between the first and second electrodes upon a solution containing at least one of protein, peptide, amino acid, and/or modified amino acid being passed in the gap established between the first and the second electrodes.
2 more elements
(canceled)
16-25. (canceled)
Dependencies are inferred from the claim text.