Method for detecting trifluridine- and/or tipiracil-related substance
AssigneeTaiho Pharmaceutical Co., Ltd.
InventorYoshinori TOKIMITSU
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Abstract
This invention provides a method that is capable of detecting a trifluridine-related substance and a tipiracil-related substance contained in a sample containing trifluridine or a salt thereof and tipiracil or a salt thereof using the same procedure. The method is for detecting a trifluridine-related substance or a tipiracil-related substance or both, the method comprising the step of subjecting a sample containing trifluridine or a salt thereof and tipiracil or a salt thereof to high-performance liquid chromatography using a mobile phase composed of an organic phase and an aqueous phase.
Claims18
A method for detecting a trifluridine-related substance or a tipiracil-related substance or both,
- subjecting a sample containing trifluridine or a salt thereof and tipiracil or a salt thereof to high-performance liquid chromatography with a mobile phase comprising an organic phase and an aqueous phase;
- and
- detecting related substances 1, 3 and 4 contained in the sample,
- wherein the related substance 1 is trifluorothymine, the related substance 3 is 5-chloro-6-{(2-oxopyrrolidin-1-yl)methyl}pyrimidine-2,4-(1H,3H)-dione, and the related substance 4 is 2′-deoxy-5-methoxycarbonyluridine.
9-12. (canceled)
Dependencies are inferred from the claim text.