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US 2019/0195753 A1Published application
Transparent skin sample
AssigneeShiseido Company, Ltd.
InventorsKentaro Kajiya, Toyonobu YAMASHITA
Life of this patent
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Abstract
The present invention address the problem of providing a transparent skin sample by removing epidermis via enzymatic treatment.
Claims20
A transparent skin sample that allows observation of subepidermal tissue under a light sheet microscope, wherein
- the transparent skin sample is not accompanied with a light-impermeable epidermis, and
- the antigenicity is maintained.
A method of producing a transparent skin sample from an obtained skin section, comprising:
- contacting the skin section with an enzyme solution for epidermis removal,
- fixing the skin section by contacting the skin section with a fixing solution, and
- contacting the skin section with a clearing reagent.
A method of treating a skin section, comprising
- contacting the skin section with an enzyme solution for epidermis removal,
- fixing the skin section by contact the skin section with a fixing solution, and
- contacting the skin section with a clearing reagent,
- in any desired order.
1 more element
Dependencies are inferred from the claim text.