Diagnosis of inflammatory bowel disease based on genes
AssigneeCedars-Sinai Medical Center
InventorsDermot P. MCGOVERN, Dalin LI
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Abstract
The present invention describes a method of prognosing high or low probability of developing an inflammatory bowel disease (IBD) in a subject and a method of diagnosing an inflammatory bowel disease (IBD) in a subject. The invention further provides for a method of identifying genes/genetic loci associated with a disease condition, such as IBD, CD and/or UC.
Claims26
A method of prognosing high or low probability of developing an inflammatory bowel disease (IBD) in a subject, comprising:
- genotyping the subject for a risk allele at a gene/genetic locus;
- and
- upon detecting the risk allele, prognosing high probability of developing the IBD in the subject;
- or upon not detecting the risk allele, prognosing low probability of developing the IBD in the subject.
A method of diagnosing an inflammatory bowel disease (IBD) in a subject, comprising:
- genotyping a sample from the subject for a risk allele at a gene/genetic locus;
- upon detecting the risk allele, diagnosing IBD in the subject;
- and
- administering the IBD therapy to the subject diagnosed with IBD, thereby treating IBD in the subject.
A method, comprising:
- genotyping a sample from the subject for a risk allele at a gene/genetic locus;
- upon detecting the risk allele, diagnosing IBD in the subject;
- and
- administering the IBD therapy to the subject diagnosed with IBD, thereby treating IBD in the subject.
A method of identifying genes/genetic loci associated with a condition, comprising:
- acquiring genetic data from samples of a cohort of the condition;
- performing a GLS transformation on the genetic data, thereby decorrelating the genetic data;
- conducting gene-based analysis on the GLS-transformed genetic data;
- and
- identifying genes/genetic loci associated with the condition.
Dependencies are inferred from the claim text.