Method for predicting a treatment response to a crhr1 antagonist and/or a v1b antagonist in a patient with depressive and/or anxiety symptoms

A method of treating a human patient with depressive and/or anxiety symptoms comprising

• administering an effective amount of a V1B receptor antagonist and/or CRHR1 antagonist to the patient in need thereof,
• wherein the patient's genome has a polymorphic variant in the AVPR1B gene, the polymorphic variant is SNP rs28373064 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 1, wherein in one or two alleles of the wild-type nucleotide A is replaced by indicator nucleotide G, or an SNP in strong linkage disequilibrium with SNP rs28373064, and
• wherein the patient's genome excluding the AVPR1B gene has at least one polymorphic variant selected from the group of biomarkers consisting of:
• SNP rs9880583 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 2, wherein in one or two alleles the wild-type nucleotide C is replaced by indicator nucleotide G,
• SNP rs13099050 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 3, wherein in one or two alleles the wild-type nucleotide A is replaced by indicator nucleotide C,
• SNP rs7441352 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 4, wherein in one or two alleles the wild-type nucleotide A is replaced by indicator nucleotide G,
• SNP rs730258 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 5, wherein in one or two alleles the wild-type nucleotide C is replaced by indicator nucleotide T,
• SNP rs12654236 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 6, wherein in one or two alleles the wild-type nucleotide A is replaced by indicator nucleotide G,
• SNP rs17091872 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 7, wherein in one or two alleles the wild-type nucleotide A is replaced by indicator nucleotide G,
• SNP rs12254219 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 8, wherein in one or two alleles the wild-type nucleotide C is replaced by indicator nucleotide T,
• SNP rs11575663 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 9, wherein in one or two alleles the wild-type nucleotide A is replaced by indicator nucleotide G,
• SNP rs7080276 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 10, wherein in one or two alleles the wild-type nucleotide A is replaced by indicator nucleotide G,
• SNP rs7416 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 11, wherein in one or two alleles the wild-type nucleotide A is replaced by indicator nucleotide G,
• SNP rs12424513 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 12, wherein in one or two alleles the wild-type nucleotide C is replaced by indicator nucleotide T,
• SNP rs1035050 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 13, wherein in one or two alleles the wild-type nucleotide C is replaced by indicator nucleotide T,
• SNP rs9959162 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 14, wherein in one or two alleles the wild-type nucleotide A is replaced by indicator nucleotide C, and
• SNP rs8088242 which is represented by a single polymorphic change at position 27 of SEQ ID NO:
• 15, wherein in one or two alleles the wild-type nucleotide A is replaced by indicator nucleotide G.