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US 2019/0194698 A1Published application
Host cells and methods for producing hydroxytyrosol
AssigneeThe Regents of the University of California
InventorsErika Yoshida, Taek Soon Lee
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Abstract
The present invention provides for a composition comprising: (a) a first host cell capable of producing L-DOPA; and (b) a modified host cell is capable of converting L-DOPA into hydroxytyrosol (HTy); wherein any one or both of the first host cell and second host cell is a genetically modified host cell.
Claims24
A composition comprising:
- (a) a first host cell capable of producing L-DOPA;
- and (b) a second host cell capable of converting L-DOPA into hydroxytyrosol (HTy);
- wherein any one or both of the first host cell and the second host cell is a genetically modified host cell.
A method for producing hydroxytyrosol (HTy) comprising:
- (a) providing a first host cell capable of producing L-DOPA;
- (b) culturing the first host cell to produce a first culture;
- (c) providing a second host cell capable of converting L-DOPA into hydroxytyrosol (HTy);
- (d) culturing the second host cell to produce a second culture;
- (e) combining or mixing the first and second cultures to produce a co-culture;
- (f) culturing the first and second host cells in the composition such that HTy is produced;
- and
- (g) optionally extracting or separating the HTy from the co-culture;
- wherein any one or both of the first host cell and the second host cell is a genetically modified host cell.
6 more elements
Dependencies are inferred from the claim text.