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US 2019/0194687 A1Published application
Efficient non-meiotic allele introgression in livestock
OwnerScott C. Fahrenkrug, Daniel F. Carlson +1inventors
InventorsScott C. Fahrenkrug, Daniel F. Carlson, Tad S. Sonstegard
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Abstract
Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.
Claims6
A method of modifying a bovine cell, the method comprising:
- contacting the bovine cell with a targeted endonuclease that targets and cuts a gene encoding the prolactin receptor;
- contacting the bovine cell with a homology-dependent repair template such that the template integrates into the genome of the bovine cell to encode a truncated prolactin receptor protein.
Dependencies are inferred from the claim text.