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US 2019/0194665 A1Published application
Methods and compositions for the specific inhibition of glycolate oxidase (hao1) by double-stranded rna
AssigneeDicerna Pharmaceuticals, Inc.
InventorsBob D. Brown, Henryk T. Dudek
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Abstract
This invention relates to compounds, compositions, and methods useful for reducing Glycolate Oxidase (HAO1) target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.
Claims29
1-85. (canceled)
A double stranded nucleic acid (dsNA), wherein the dsNA comprises:
- (a) a first nucleic acid strand, wherein:
- (i) the first nucleic acid strand is 15-27 nucleotides in length;
- and
- (ii) the first nucleic acid strand comprises one or more modified nucleotides;
- and
- (b) a second nucleic acid strand, wherein:
- (i) the second nucleic acid strand is 19-27 nucleotides in length;
- (ii) the second nucleic acid strand comprises one or more modified nucleotides;
- and
- (iii) the second nucleic acid strand is complementary to SEQ ID NO:
- 1823 along at least 19 consecutive nucleotides in length.
8 more elements
Dependencies are inferred from the claim text.