Use of rad18 inhibitors in the treatment of tumors
AssigneeCentre National De La Recherche Scientifique
InventorDomenico Maiorano
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Abstract
The present invention relates to the use of an inhibitor of Rad18 expression or activity, in treating a tumor or in sensitizing a patient affected with a tumor, to a treatment with an antineoplastic agent that is a DNA damaging chemotherapeutic agent so to both reduce the self renewal of cancer stem cells and increase the DNA damage response thus boosting apoptotic cell death.
Claims17
A method for treating a tumor that is resistant to a treatment with a DNA damaging antineoplastic agent, in a patient, said method comprising administering to a patient in need thereof a therapeutically effective amount of an inhibitor of Rad18 expression or activity.
A method for determining whether a tumor is resistant or, is expected to be resistant, to a therapy with a DNA damaging antineoplastic agent, which method comprises determining the expression level of Rad18 in the tumor, wherein a higher expression compared to a control is indicative of the presence of cancer stem cells which are resistant to a therapy with a DNA damaging antineoplastic agent.
A method for determining whether a patient treated for a tumor is at risk of a cancer relapse, which method comprises determining the expression level of Rad18 in the tumor or in a biological sample of the patient, preferably a tumor sample, wherein a higher expression compared to a control is indicative of the presence of cancer stem cells which are likely to develop and cause a cancer relapse.
A method for monitoring efficacy of an anti-tumor treatment in a patient affected with a tumor which comprises cancer stem cells, which method comprises determining the expression level of Rad18 in the tumor or a biological sample of the patient, preferably a tumor sample, wherein a higher expression compared to a control is indicative of the presence of residual cancer stem cells.
Dependencies are inferred from the claim text.