Endolysin variant

A polypeptide comprising an amino acid sequence exhibiting at least 90% sequence identity with the sequence of SEQ ID NO:

• 10, wherein SEQ ID NO:
• 10 is characterized by
• X2 may be any amino acid, preferably D or N,
• X5 may be any amino acid, preferably L, I or V,
• X6 may be any amino acid, preferably H or K,
• X13 may be any amino acid, preferably G, V or S,
• X15 may be any amino acid, preferably R or Q,
• X20 may be any amino acid, preferably K or R,
• X23 may be any amino acid, preferably K or P,
• X24 may be any amino acid, preferably S or N,
• X28 may be any amino acid, preferably L or F,
• X32 may be any amino acid, preferably Y or F,
• X34 may be any amino acid, preferably H or S,
• X37 may be any amino acid, preferably A or P,
• X38 may be any amino acid, preferably D or H,
• X40 may be any amino acid, preferably K or Y,
• X49 may be any amino acid, preferably Q or R,
• X55 may be any amino acid, preferably H or N,
• X56 may be any amino acid, preferably K or R,
• X59 may be any amino acid, preferably V, S or A,
• X72 may be any amino acid, preferably P, L, T or S,
• X81 may be any amino acid, preferably M or V,
• X90 may be any amino acid, preferably V, P or A,
• X95 may be any amino acid, preferably A or V,
• X98 may be any amino acid, preferably G or D,
• X108 may be any amino acid, preferably V, I or A,
• X109 may be any amino acid, preferably A or S,
• X113 may be any amino acid, preferably N or S,
• X116 may be any amino acid, preferably S or T;
• with the proviso that the polypeptide does neither comprise the sequence according to SEQ ID NO:2, nor the sequence according to SEQ ID NO:3, nor the sequence according to SEQ ID NO:4, nor consists of a sequence according to SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, or SEQ ID NO:31.