Compositions and methods for biological production of amino acids in hydrogenotrophic microorganisms
AssigneeTrelys, Inc.
InventorsJill Bradshaw, Zhihao Hu, Jay Kouba
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Abstract
The present disclosure provides compositions and methods for using hydrogenotrophic microorganisms capable of biologically utilizing or converting H2 and CO and/or CO2 gas into high-value molecules and biological material, such as essential amino acids (e.g., lysine, threonine, methionine) and animal feed.
Claims41
A process for producing amino acids, the process comprising feeding a gaseous mixture comprising COx and H2 where X is 1 and/or 2, a nitrogen source, and optionally a sulfur source to a bioreactor that contains non-natural hydrogenotrophic microorganism under conditions such that the non-natural hydrogenotropic microorganism produces amino acids at a higher level than a parent hydrogenotrophic microorganism.
A process for producing amino acids from a H2/COx substrate, the process comprising:
- (a) feeding the substrate into a reactor under conditions to generate a gaseous mixture comprising COx and H2, where x is 1 and/or 2;
- and
- (b) feeding the gaseous mixture, a nitrogen source, and optionally a sulfur source to a bioreactor that contains non-natural hydrogenotrophic microorganisms under conditions such that the non-natural hydrogenotropic microorganisms produce amino acids at a higher level than a parent hydrogenotrophic microorganism.
A system for preparing amino acids, the system comprising:
- (a) a reactor that converts a H2/COx substrate into a gaseous mixture comprising COx and H2, where x is 1 and/or 2;
- and
- (b) a bioreactor containing non-natural hydrogenotrophic microorganisms that convert the gaseous mixture to amino acids at a higher level than a parent hydrogenotrophic microorganism.
Dependencies are inferred from the claim text.