Human Extensively Self-Renewing Erythroblasts (ESRE)
AssigneeUniversity of Rochester
InventorsJames Palis, Samantha England, Ah Ram Kim
Life of this patent
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Abstract
The present invention provides a human cell population that can self-renew extensively and yet retain the capacity to differentiate into red blood cells (RBCs). These cells are referred to as extensively self-renewing erythroblasts (ESREs). The cells of the invention serve among other things as a renewable source of transfusable RBCs.
Claims20
1-5. (canceled)
A composition comprising:
- an isolated population of human ESRE and
- an expansion medium comprising Epo, SCF, dexamethasone, and a lipid mixture.
8-17. (canceled)
A method of delivering a gene to a mammal, the method comprising administering a gene delivery vehicle to the mammal wherein the vehicle comprises an extensively self-renewing erythroblast (ESRE) that is genetically modified to express one or more therapeutic proteins.
A method of generating a human red blood cell (RBC), the method comprising culturing an extensively self-renewing erythroblast (ESRE) in a differentiation medium comprising EPO and insulin.
20-33. (canceled)
Dependencies are inferred from the claim text.