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US 2019/0194590 A1Published application
Polygonal scaffold and manufacturing method thereof, and protein modulator and manufacturing method thereof
AssigneeNational Tsing Hua University
InventorsSheng-Kai WANG, Cin-Hao LIN
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Abstract
A polygonal scaffold includes at least three polyproline II (PPII) helix rods and at least three connectors. Each of the PPII helix rods is composed of a plurality of repeat units represented by Formula (i), and at least one of the PPII helix rods has at least one of hydrogen atoms of at least one of the repeat units being substituted by a first chemical handle for connecting a ligand. Each of the connectors is a divalent organic group, and every two of the PPII helix rods are connected by one of the connectors to form a closed ring.
Claims24
A polygonal scaffold, comprising:
- at least three polyproline II (PPII) helix rods, wherein each of the PPII helix rods is composed of a plurality of repeat units represented by Formula (i):
- wherein at least one of the PPII helix rods has at least one of hydrogen atoms of at least one of the repeat units being substituted by a first chemical handle for connecting a ligand;
- and
- at least three connectors, wherein each of the connectors is a divalent organic group, and every two of the PPII helix rods are connected by one of the connectors to form a closed ring.
1 more element
A protein modulator, comprising:
- a polygonal scaffold, comprising:
- at least three PPII helix rods, wherein each of the PPII helix rods is composed of a plurality of repeat units represented by Formula (i):
- wherein at least one of the PPII helix rods has at least one of hydrogen atoms of at least one of the repeat units being substituted by a linker;
- and
- at least three connectors, wherein each of the connectors is a divalent organic group, and every two of the PPII helix rods are connected by one of the connectors to form a closed ring;
- and
- at least one ligand, wherein the ligand is connected with one of the PPII helix rods through the linker.
4 more elements
Dependencies are inferred from the claim text.