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US 2019/0194390 A1Published application
Amino-polyesters for drug delivery
OwnerUmberto Capasso Palmiero, Piotr S. Kowalski +2inventors
InventorsUmberto Capasso Palmiero, Piotr S. Kowalski, Davide Moscatelli, Daniel Griffith Anderson
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Abstract
Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize amino-polyesters (APEs). The APEs are shown to be effective biodegradable carriers for drug delivery applications.
Claims31
A compound of Formula (I):
- wherein:
- X is O, S, or NR4;
- R is optionally substituted heteroaliphatic, optionally substituted heterocyclyl, or a combination thereof, wherein R comprises one or more amine moieties, and wherein all of said amine moieties are tertiary;
- each R1 independently is optionally substituted aliphatic or optionally substituted heteroaliphatic;
- R′ is hydrogen or a group of the formula:
- wherein:
- each R2 and R3 independently is hydrogen, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl;
- or
- R2 and R3 are combined to form an optionally substituted heterocyclyl;
- each R4 independently is hydrogen, optionally substituted aliphatic, or optionally substituted heteroaliphatic;
- each n independently is an integer between 1 and 20, inclusive;
- and
- m is an integer between 1 and 10, inclusive.
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Dependencies are inferred from the claim text.