Biodegradable network polymers for regenerative medicine and tissue engineering
AssigneeThe University of Melbourne
InventorsAnton Blencowe, Berkay Ozcelik, Greg Guanghua Qiao
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Abstract
Biodegradable polyether network polymers crosslinked via ester linkages, to substrates, implants and scaffolds including the biodegradable polyether network polymers; methods for preparing such network polymers, implants and scaffolds; and methods of using substrates, implants and scaffolds including the network polymers, particularly for culturing cells and regenerating tissue.
Claims35
A biodegradable polyether network polymer crosslinked via ester linkages which is prepared by polymerising a monomer composition comprising a multifunctional polyether monomer and a multifunctional crosslinking monomer, wherein one of the polyether monomer and the crosslinking monomer comprises a hydroxy functional group and the other of the polyether monomer and the crosslinking monomer comprises a complementary functional group capable of reacting with the hydroxy functional group to form an ester linkage, and wherein at least one selected from the polyether monomer and the crosslinking monomer is branched.
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A process for preparing a biodegradable polyether network polymer crosslinked via ester linkages, the process comprising the step of reacting a monomer composition comprising a multifunctional polyether monomer and a multifunctional crosslinking monomer under conditions allowing formation of ester linkages between the polyether monomer and the crosslinking monomer, wherein one of the polyether monomer and the crosslinking monomer comprises a hydroxy functional group and the other of the polyether monomer and the cros slinking monomer comprises a complementary functional group capable of reacting with the hydroxy functional group to form an ester linkage, and wherein at least one selected from the polyether monomer and the crosslinking monomer is branched.
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