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AssigneeAuckland Uniservices Limited
InventorsJadranka Travas-Sejdic, David Edward Williams, Nihan Aydemir, David Barker, Wai Chi Eddie Chan, Clive William Evans
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The present invention generally relates to the field of conducting polymers. More specifically, the present invention relates to polymerisable monomers comprising a probe capable of binding one or more nucleic acids or comprising a nucleic acid or an analogue thereof, conducting polymers comprising monomer units of such monomers, and methods of making such polymers. The present invention also relates to sensors comprising the polymers, sensor systems comprising the sensors, methods of making the sensors, and methods for determining the presence or absence or amount of targets employing the sensors. The present invention also relates to methods, systems and apparatuses for amplifying nucleic acids employing the conducting polymers.
A polymerisable monomer of formula (1):
The polymerisable monomer of any one if the preceding claims, wherein p is 2.
The polymerisable monomer of any one of the preceding claims, wherein
The polymerisable monomer of any one of the preceding claims, wherein R1, R2, R3, and R4 are each hydrogen;
The polymerisable monomer of any one of the preceding claims, wherein R1 and R4 are identical and R2 and R3 are identical;
The polymerisable monomer of any one of the preceding claims, wherein R1, R2, R3, and R4 are each hydrogen.
The polymerisable monomer of any one of the preceding claims, wherein Z1 and Z2 are each S;
The polymerisable monomer of any one of the preceding claims, wherein Ra at each instance is hydrogen.
The polymerisable monomer of any one of the preceding claims, wherein the polymerisable monomer has the formula (1C) or (1D):
The polymerisable monomer of any one of the preceding claims, wherein the polymerisable monomer has an oxidation potential for polymerisation of from about 0 to about 1.0V vs. Ag/AgCl (3 M KCl), for example from about 0.2 to 1.0, 0.3 to 1.0, 0.4 to 1.0, 0.5 to 1.0, 0.6 to 1.0, 0.7 to 1.0, 0.8 to 1.0, 0.2 to 0.9, 0.3 to 0.9, 0.4 to 0.9, 0.5 to 0.9, 0.6 to 0.9, 0.7 to 0.9, or 0.8 to 0.9V vs. Ag/AgCl (3 M KCl).
The polymerisable monomer of any one of the preceding claims, wherein the linker group has the formula:
The polymerisable monomer of any one of the preceding claims, wherein X3 is selected from the group consisting of —C(═NH)NH—, —NHC(═NH)—, —C(O)NH—, —NHC(O)—, —C(O)O—, —OC(O)—, —NHC(O)CRvRwS—, —SCRwRvC(O)NH—, —SS—, —C(O)NHN═CH—, —CH═NNHC(O)—, —CH═N—, —N═CH—,
The polymerisable monomer of any one of the preceding claims, wherein the linker group is —O—(CH2)m—C(O)NH—, wherein m is an integer from 2 to 8.
The polymerisable monomer of any one of the preceding claims, wherein the probe is capable of binding one or more nucleic acids in a sequence specific manner.
The polymerisable monomer of any one of the preceding claims, wherein the probe comprises a single or double stranded oligonucleotide, polynucleotide, or an analogue thereof.
The polymerisable monomer of any one of the preceding claims, wherein the probe comprises an aptamer.
A conducting polymer comprising a monomer unit of the formula (2):
Dependencies are inferred from the claim text.