Long-acting pcsk9-specific binding protein and application thereof
AssigneeChangzhou Bojia Biotechnology Co., Ltd
InventorShaoxiong Wang
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Abstract
Provided is a long-acting PCSK9-specific binding protein and application thereof. Provided is an MV072 protein with unique complementarity-determining regions, i.e., a binding protein specifically binding to proprotein convertase subtilisin kexin type 9 (PCSK9). The protein can specifically bind to PCSK9, effectively inhibit the function of PCSK9 and reduce plasma LDL cholesterol level. Further provided is an application of the binding protein in treating diseases related to or influenced by the function of PCSK9.
Claims19
-15. (canceled)
A binding protein MV072 that specifically binds to PCSK9, wherein the binding protein MV072 has a light chain variable region and a heavy chain variable region, and
- the amino acid sequence of the heavy chain variable region CDR1 thereof is set forth in SEQ ID NO:
- 7;
- the amino acid sequence of the heavy chain variable region CDR2 thereof is set forth in SEQ ID NO:
- 8 or SEQ ID NO:
- 13;
- the amino acid sequence of the heavy chain variable region CDR3 thereof is set forth in SEQ ID NO:
- 9 or SEQ ID NO:
- 14;
- the amino acid sequence of the light chain variable region CDR1 thereof is set forth in SEQ ID NO:
- 10;
- the amino acid sequence of the light chain variable region CDR2 thereof is set forth in SEQ ID NO:11;
- and
- the amino acid sequence of the light chain variable region CDR3 thereof is set forth in SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.