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US 2019/0194355 A1Published application
Compositions and Methods to Regulate Renalase in the Treatment of Cancer
AssigneeYale University
InventorsGary Desir, Abigail Hunt, Jessica O-Rear, Peter Flynn
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Abstract
The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.
Claims13
1-36. (canceled)
A composition comprising an isolated monoclonal antibody, wherein the antibody comprises:
- a) the heavy chain CDR1 sequence of SEQ ID NO:35;
- b) the heavy chain CDR2 sequence of SEQ ID NO:36;
- c) the heavy chain CDR3 sequence of SEQ ID NO:37;
- d) the light chain CDR1 sequence of SEQ ID NO:38;
- e) the light chain CDR2 sequence of SEQ ID NO:39;
- and f) the light chain CDR3 sequence of SEQ ID NO:40.
3 more elements
Dependencies are inferred from the claim text.