Bcma antibodies and use of same to treat cancer and immunological disorders
AssigneeSeattle Genetics, Inc.
InventorsDjango Sussman, Maureen Ryan, Lori Westendorf, Michael Feldhaus
Life of this patent
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Abstract
The invention provides humanized antibodies that specifically bind to BCMA. The antibodies are useful for treatment and diagnoses of various cancers and immune disorders as well as detecting BCMA.
Claims94
A humanized, chimeric or veneered antibody, which is a humanized, chimeric or veneered form of an antibody deposited as ATCC PTC-6937.
A pharmaceutical composition comprising an antibody of any preceding claim and a pharmaceutically acceptable carrier.
A humanized, chimeric or veneered antibody, which is a humanized, chimeric or veneered form of the rat SG16.45 antibody having a mature heavy chain variable region of SEQ ID NO:
- 23 and a mature light chain variable region of SEQ ID NO:
- 33.
A humanized antibody the specifically binds to the human BCMA protein, the antibody comprising a mature heavy chain variable region having at least 90% sequence identity to hSG16.17 VH3 (SEQ ID NO:
- 13) and a mature light chain variable region having at least 90% sequence identity to hSG16.17 VK2 (SEQ ID NO:
- 19).
A nucleic acid encoding a mature heavy chain variable region and/or a mature light chain variable region of a humanized antibody that specifically binds to the human BCMA protein, the antibody comprising a mature heavy chain variable region having at least 90% sequence identity to hSG16.17 VH3 (SEQ ID NO:
- 13) and a mature light chain variable region having at least 90% sequence identity to hSG16.17 VK2 (SEQ ID NO:
- 19).
A first and a second vector comprising nucleic acids that encode the sequence of hSG16.17 VH3 (SEQ ID NO:
- 13) and the sequence of hSG16.17 VK2 (SEQ ID NO:
- 19), respectively.
A nucleic acid encoding a mature heavy chain variable region and/or a mature light chain variable region of a humanized antibody that specifically binds to the human BCMA protein, the antibody a mature heavy chain variable region having at least 90% sequence identity to hSG16.45 VH5 (SEQ ID NO:
- 31) and a mature light chain variable region having at least 90% sequence identity to hSG16.45 VK2 (SEQ ID NO:
- 36).
Dependencies are inferred from the claim text.