Humanized Anti-IL-1R3 Antibodies

Humanized antibody that specifically binds to IL-1R3 or a fragment or derivative thereof that contains at least a portion of said antibody that is sufficient to confer IL-1R3 binding specificity, comprising:

• a) a heavy chain variable region (VH) comprising the complementary determining regions comprising CDR-H1, CDR-H2, and CDR-H3
• wherein the CDR-H1 region comprises an amino acid sequence selected from the group of SEQ ID NO:
• 69-85,
• wherein the CDR-H2 region comprises an amino acid sequence selected from the group of SEQ ID NO:
• 86-102,
• and wherein the CDR-H3 region comprises an amino acid sequence selected from the group of SEQ ID NO:
• 103-119;
• and
• b) a light chain variable region (VL) comprising the complementary determining regions comprising CDR-L1, CDR-L2, and CDR-L3
• wherein the CDR-L1 region comprises an amino acid sequence selected from the group of SEQ ID NO:
• 120-136,
• wherein the CDR-L2 region comprises an amino acid sequence selected from the group of SEQ ID NO:
• 137-153, and
• wherein the CDR-L3 region comprises an amino acid sequence selected from the group of SEQ ID NO:
• 154-170, and SEQ ID NO:
• 175.