Anti-tem1 antibodies and uses thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsNathalie Scholler, Alzhi Zhao, Donald Siegel, George Coukos
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Abstract
The invention relates to Anti-TEM 1 antibodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.
Claims7
-36. (canceled)
A method of diagnosing the presence of a tumor or a cancer growth in a subject, said method comprising sampling a tissue sample isolated from said subject with a composition comprising an antibody or antigen-binding fragment thereof, wherein said antibody or antigen-binding fragment is specific for both the mouse and human form of an endosialin tumor endothelial marker 1 (TEM1) and binds to an epitope sequence as set forth in SEQ ID NO:
- 40, wherein the antibody or antigen-binding fragment comprises a heavy chain variable region comprising a CDR1 sequence of residues 31 to 35 of SEQ ID NO:
- 43;
- a CDR2 sequence of residues 50 to 65 of SEQ ID NO:
- 43;
- and
- a CDR3 sequence of residues 98 to 102 of SEQ ID NO:
- 43, and wherein the antibody or antigen-binding fragment comprises a light chain variable region comprising a CDR1 sequence of residues 23 to 36 of SEQ ID NO:
- 48;
- a CDR2 sequence of residues 52 to 62 of SEQ ID NO:
- 48;
- and a CDR3 sequence of residues 97 to 104 of SEQ ID NO:
- 48, whereby specific binding of said antibody or antigen-binding fragment to said tissue sample is indicative of the presence of a tumor or cancer growth in said subject.
-76. (canceled)
Dependencies are inferred from the claim text.