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US 2019/0194330 A1Published application
Methods of sensitizing cancer to immunotherapy
AssigneeCase Western Reserve University
InventorsAlex Yee-Chen Huang, Agne Petrosiute
Life of this patent
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Abstract
A method of sensitizing cancer to immunotherapy in a subject in need thereof includes administering to the subject a therapeutically effective amount of a CdK5 inhibitor to suppress immune checkpoint PD-L1.
Claims17
A method of sensitizing cancer to immunotherapy or treating tumor immunity in a subject in need thereof, comprising:
- administering to the subject a therapeutically effective amount of a CdK5 inhibitor to suppress immune checkpoint Programmed Death-Ligand 1 (PD-L1).
A method of sensitizing cancer to immunotherapy or treating tumor immunity in a subject in need thereof, comprising:
- detecting the expression level of Cdk5 and/or Programmed Death-Ligand 1 (PD-L1) in cancer cells;
- and
- administering a subject having cancer cells expressing or over-expressing Cdk5 and/or PD-L1 an amount of a CdK5 inhibitor effective to suppress immune checkpoint PD-L1.
17-32. (canceled)
Dependencies are inferred from the claim text.