Antibodies to lilrb2
AssigneeJounce Therapeutics, Inc.
InventorsHeather B. COHEN, Lauren Pepper MACKENZIE, Yasmin RAMSAY, Donald Raymond SHAFFER, Jeffrey Yan-Fei SMITH, Kristin Shanea O'MALLEY, Kevin Patrick GUAY
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Abstract
Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.
Claims30
An antibody that specifically binds to human LILRB2, wherein the antibody comprises the following complementarity determining regions (CDRs):
- (a) a CDR-H1 comprising the amino acid sequence of
- JY(J)2G(J)2 (SEQ ID NO:
- 171);
- (b) a CDR-H2 comprising the amino acid sequence of
- (J)2W(J)11KJ (SEQ ID NO:
- 172);
- (c) a CDR-H3 comprising the amino acid sequence of
- (J)2I(J)3TDYV(J)3 (SEQ ID NO:
- 173);
- (d) a CDR-L1 comprising the amino acid sequence of
- (J)8DLJ (SEQ ID NO:
- 174);
- (e) a CDR-L2 comprising the amino acid sequence of
- (J)7 (SEQ ID NO:
- 175);
- and
- (f) a CDR-L3 comprising the amino acid sequence of
- (J)3YJYPLJ (SEQ ID NO:
- 176),
- wherein each J is independently a naturally occurring amino acid.
4-8. (canceled)
10-12. (canceled)
(canceled)
An antibody that specifically binds to human LILRB2, wherein the antibody comprises the following six complementarity determining regions (CDRs):
- (a) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 15;
- (b) a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 16;
- (c) a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 17;
- (d) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 18;
- (e) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 19;
- and
- (f) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 20.
21-41. (canceled)
43-50. (canceled)
An antibody that (i) specifically binds to human LILRB2 and blocks the binding of HLA-G and/or HLA-A2 to human LILRB2, or (ii) specifically binds to human LILRB2, wherein said antibody is capable of converting an M2-like macrophage to an M1-like macrophage.
53-70. (canceled)
72-76. (canceled)
(canceled)
(canceled)
84-96. (canceled)
Dependencies are inferred from the claim text.