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US 2019/0194326 A1Published application
Treatment and sustained virologic remission of hiv infection by antibodies to cd4 in haart stabilized patients
AssigneeUbi US Holdings, LLC.
InventorChang Yi WANG
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Abstract
The present disclosure is directed to compositions and methods for the prevention, treatment, and/or functional cure of HIV infection. One aspect of the present disclosure relates to monoclonal antibodies directed against CD4, compositions thereof, and methods employing such compositions for the prevention, treatment, and functional cure of HIV infection.
Claims65
An antibody directed against a CD4 molecule, wherein
- the antibody specifically binds to an extracellular region of the CD4 molecule, and wherein
- when the antibody is bound to the CD4 molecule on the surface of a CD4+ cell, the antibody:
- a) competitively inhibits HIV entry into the CD4+ cell;
- b) activates latent HIV reservoirs in a resting CD4+ cell infected with HIV;
- d) reduces levels of cellular HIV DNA;
- and
- e) provides sustained virologic remission of HIV infection without viral load rebound.
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Dependencies are inferred from the claim text.