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US 2019/0194319 A1Published application
Anti-ascl1 antibodies and methods of use
AssigneeAbbvie Stemcentrx LLC
InventorsJEFFREY BERNSTEIN, LAURA SAUNDERS, SHEILA BHEDDAH, ENYING YOU, CASEY FRANKLIN, TIEN YIN YAU, GRAYSON KOCHI
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Abstract
Compositions comprising Achaete-scute homolog 1 (ASCL1) antibodies, and methods comprising ASCL1 antibody compositions for detecting ASCL1 expression as a diagnostic biomarker, are provided.
Claims39
An isolated anti-ASCL1 antibody that comprises or competes for binding to a human ASCL1 protein with an antibody comprising:
- a light chain variable region (VL) of SEQ ID NO:
- 21 and a heavy chain variable region (VH) of SEQ ID NO:
- 23;
- or
- a VL of SEQ ID NO:
- 25 and a VH of SEQ ID NO:
- 27;
- or
- a VL of SEQ ID NO:
- 29 and a VH of SEQ ID NO:
- 31;
- or
- a VL of SEQ ID NO:
- 33 and a VH of SEQ ID NO:
- 35;
- or
- a VL of SEQ ID NO:
- 37 and a VH of SEQ ID NO:
- 39;
- or
- a VL of SEQ ID NO:
- 41 and a VH of SEQ ID NO:
- 43;
- or
- a VL of SEQ ID NO:
- 45 and a VH of SEQ ID NO:
- 47;
- or
- a VL of SEQ ID NO:
- 49 and a VH of SEQ ID NO:
- 51;
- or
- a VL of SEQ ID NO:
- 53 and a VH of SEQ ID NO:
- 55;
- or
- a VL of SEQ ID NO:
- 57 and a VH of SEQ ID NO:
- 59;
- or
- a VL of SEQ ID NO:
- 61 and a VH of SEQ ID NO:
- 63;
- or
- a VL of SEQ ID NO:
- 65 and a VH of SEQ ID NO:
- 67;
- or
- a VL of SEQ ID NO:
- 69 and a VH of SEQ ID NO:
- 71;
- or
- a VL of SEQ ID NO:
- 21 and a VH of SEQ ID NO:
- 73.
52 more elements
Dependencies are inferred from the claim text.