Peptide compounds for suppressing inflammation
AssigneeDuke University
InventorsDaniel T. Laskowitz, Hana Dawson, Brad Kolls
Life of this patent
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Abstract
Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.
Claims17
A peptide of Formula I:
- X1-X2-X3-X4-X5 (SEQ ID NO:1)
- or a salt thereof, wherein
- X1 is selected from an amino acid having a hydrophobic side chain or an amino acid having a positively charged side chain;
- X2 is selected from an amino acid having a hydrophobic side chain, an amino acid having a positively charged side chain, or an amino acid having a polar uncharged side chain;
- X3 is selected from an amino acid having a positively charged side chain;
- X4 is selected from an amino acid having a positively charged side chain;
- and
- X5 is selected from an amino acid having a hydrophobic side chain or an amino acid having a positively charged side chain.
A method of reducing inflammation in a subject in need thereof, the method comprising administering to the subject an effective amount of a peptide of Formula I:
- X1-X2-X3-X4-X5 (SEQ ID NO:1)
- or a salt thereof, wherein
- X1 is selected from an amino acid having a hydrophobic side chain or an amino acid having a positively charged side chain;
- X2 is selected from an amino acid having a hydrophobic side chain, an amino acid having a positively charged side chain, or an amino acid having a polar uncharged side chain;
- X3 is selected from an amino acid having a positively charged side chain;
- X4 is selected from an amino acid having a positively charged side chain;
- and
- X5 is selected from an amino acid having a hydrophobic side chain or an amino acid having a positively charged side chain.
A method of treating a neurological condition in a subject in need thereof, the method comprising administering to the subject a composition comprising an effective amount of a peptide of Formula I:
- X1-X2-X3-X4-X5 (SEQ ID NO:1)
- or a salt thereof, wherein
- X1 is selected from an amino acid having a hydrophobic side chain or an amino acid having a positively charged side chain;
- X2 is selected from an amino acid having a hydrophobic side chain, an amino acid having a positively charged side chain, or an amino acid having a polar uncharged side chain;
- X3 is selected from an amino acid having a positively charged side chain;
- X4 is selected from an amino acid having a positively charged side chain;
- and
- X5 is selected from an amino acid having a hydrophobic side chain or an amino acid having a positively charged side chain.
Dependencies are inferred from the claim text.