Peptide vaccine for prevention and immunotherapy of dementia of the alzheimer's type
AssigneeUnited Biomedical, Inc.
InventorChang Yi Wang
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Abstract
The present disclosure is directed to individual Aβ peptide immunogen constructs, peptide compositions comprising these Aβ peptide immunogen constructs and mixtures thereof, pharmaceutical compositions including vaccine formulations comprising these Aβ peptide immunogen constructs, with the individual Aβ peptide immunogen constructs having the N-terminus of the Aβ peptide as the B cell (B) epitopes linked through spacer residue(s) to heterologous T helper cell (Th) epitopes derived from pathogen proteins that act together to stimulate the generation of highly specific antibodies directed against the N-terminus of the Aβ peptide offering protective immune responses to patients at risk for, or with, Alzheimer's Disease.
Claims20
An Aβ peptide immunogen construct comprising the following formula:
- (N-terminal fragment of Aβ1-42peptide)-(A)o-(Th)—X
- wherein (N-terminal fragment of Aβ1-42 peptide) is a B cell epitope from Aβ comprising about 10 to about 14 amino acid residues selected from the group consisting of SEQ ID NOs:
- 4, 5, and 6;
- each A is independently an amino acid or a linking group selected from the group consisting of an amino acid, Lys-, Gly-, Lys-Lys-Lys-, (α, ε-N)Lys, and ε-N-Lys-Lys-Lys-Lys (SEQ ID NOs:
- 32);
- each Th comprises an amino acid sequence that constitutes a helper T cell epitope selected from the group consisting of SEQ ID NOs:
- 34, 37, 38, 40 to 47 and functional immunological analogues thereof;
- X is an α-COOH or α-CONH2 of an amino acid;
- and
- o is from 0 to about 4.
Dependencies are inferred from the claim text.