Wound Healing Peptide
OwnerAlex Loukas, Michael Smout +1inventors
InventorsAlex Loukas, Michael Smout, Norelle Daly
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Abstract
Peptides derived from the N-terminal region of granulin have activity in promoting cell proliferation, migration and/or wound healing. Furthermore, an additional disulphide bond may be engineered into such peptides to improve or otherwise modify the folding of the peptide. The peptides may also be modified such as at proline residues improve the ability of the peptide to promote cell proliferation.
Claims26
An isolated peptide comprising, consisting essentially of, or consisting of the amino acid sequence:
- 1Xn C 2XD 3XVYTCR 4XGQTC C/A RGLHGYGC 5Xm (SEQ ID NO:
- 1) or an amino acid sequence at least 70% identical thereto.
A method of modifying a peptide with an amino acid sequence set forth in any one of SEQ ID NOS:
- 1-11, or an amino acid sequence at least 70% identical thereto, including the step of incorporating one or more amino acid insertions, deletions, or substitutions into the amino acid sequence of the peptide.
Dependencies are inferred from the claim text.