Materials and methods for treating cancer
AssigneeMayo Foundation for Medical Education and Research
InventorHaojie Huang
Life of this patent
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Abstract
This document provides methods and materials for treating cancer (e.g., chemotherapeutic resistant cancer). For example, compositions containing a phosphorylation-mimicking peptide (e.g., a phosphorylation-mimicking FOXO1-derived peptide) to treat a mammal having cancer (e.g., to reduce the number of cancer cells in a mammal) and methods of using such compositions are provided. This document also provides methods of treating a mammal having cancer (e.g., to reduce the number of cancer cells in a mammal) by administering a phosphorylation-mimicking FOXO1-derived peptide to the mammal.
Claims29
A phosphorylation-mimicking forkhead box class O1 (FOXO1) derived peptide comprising a modification at position 319.
A method for treating cancer in a mammal, the method comprising:
- identifying said mammal as having cancer;
- and
- administering to the mammal a phosphorylation-mimicking FOXO1 derived peptide comprising a modification acid at position 319.
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A method for decreasing polypeptide expression in cells, the method comprising:
- contacting the cells with a phosphorylation-mimicking FOXO1 derived peptide comprising a glutamic acid at position 319;
- wherein expression of one or more of GLUT1, LDHA, and/or PKM2 is decreased.
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Dependencies are inferred from the claim text.