Prevention, treatment and diagnosis of p.gingivalis infection
AssigneeOral Health Australia Pty Ltd
InventorsEric Charles REYNOLDS, Neil Martin O'BRIEN SIMPSON, Keith J. CROSS, Nada SLAKESKI
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Abstract
The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
Claims21
-70. (canceled)
A chimeric or fusion protein for inducing an immune response to P. gingivalis, the protein comprising a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein:
- (A) said first peptide comprises a region of a P. gingivalis trypsin-like enzyme selected from the group consisting of:
- (i) part of, or all of a sequence that is the same as, or homologous to the sequence shown in SEQ ID No:1;
- and
- (ii) part of, or all of a sequence that is the same as, or homologous to the sequence shown in SEQ ID No:2;
- and
- (B) said second peptide or polypeptide comprises an adhesin domain of P. gingivalis, or fragment thereof, selected from the group consisting of:
- (i) part of, or all of a sequence that is the same as, or homologous to the sequence of an adhesin domain of the Lys-X-proteinase of P. gingivalis;
- (ii) part of, or all of a sequence that is the same as, or homologous to the sequence of an adhesin domain of the Arg-X-proteinase of P. gingivalis;
- and
- (iii) part of, or all of a sequence that is the same as, or homologous to the sequence of a HagA adhesin domain of P. gingivalis.
A chimeric or fusion protein according to claim 90 wherein the first peptide comprises or consists of a sequence shown in one of more of SEQ ID No:
- 3 to 26 or one or more of SEQ ID No:
- 64 to 68.
A chimeric or fusion protein for inducing an immune response to P. gingivalis, comprising:
- (A) a first peptide with a sequence from a P. gingivalis trypsin-like enzyme selected from the group consisting of KAS1 (SEQ ID NO:
- 27), KAS2 (SEQ ID NO:
- 28), KAS3 (SEQ ID NO:
- 29), PAS1K (SEQ ID NO:
- 30), KAS4 (SEQ ID NO:
- 64), KASS (SEQ ID NO:
- 65), KAS6 (SEQ ID NO:
- 66), RAS1 (SEQ ID NO:
- 31), RAS2 (SEQ ID NO:
- 32), RAS3 (SEQ ID NO:
- 33), RAS4 (SEQ ID NO:
- 67), RASS (SEQ ID NO:
- 68), and PAS1R (SEQ ID NO:
- 34), and
- (B) a second peptide or polypeptide comprises an adhesin domain of P. gingivalis, or fragment thereof, (i) selected from the group consisting of KA1 (SEQ ID NO:
- 35), KA2 (SEQ ID NO:
- 40), KA3 (SEQ ID NO:
- 41), KA4 (SEQ ID NO:
- 42), KA5 (SEQ ID NO:
- 43), RA1 (SEQ ID NO:
- 38), RA2 (SEQ ID NO:
- 44), RA3 (SEQ ID NO:
- 45), RA4 (SEQ ID NO:
- 46), HA1 (SEQ ID NO:
- 80), HA1* (SEQ ID NO:
- 81), HA1** (SEQ ID NO:
- 82), or (ii) selected from the group consisting of SEQ ID NOs.:
- 69-79, or (iii) selected from the group consisting of SEQ ID NOs.:
- 83-85.
A chimeric or fusion protein for inducing an immune response to P. gingivalis, comprising at least two sequences that are the same as, or homologous to a sequence from a P. gingivalis trypsin-like enzyme selected from the group consisting of KAS1 (SEQ ID NO:
- 27), KAS2 (SEQ ID NO:
- 28), KAS3 (SEQ ID NO:
- 29), PAS1K (SEQ ID NO:
- 30), KAS4 (SEQ ID NO:
- 64), KASS (SEQ ID NO:
- 65), KAS6 (SEQ ID NO:
- 66), RAS1 (SEQ ID NO:
- 31), RAS2 (SEQ ID NO:
- 32), RAS3 (SEQ ID NO:
- 33), RAS4 (SEQ ID NO:
- 67), RASS (SEQ ID NO:
- 68), and PAS1R (SEQ ID NO:
- 34);
- and at least one sequence that comprises an adhesin domain of P. gingivalis, or fragment thereof, selected from:
- (i) part of, or all of a sequence that is the same as, or homologous to the sequence of an adhesin domain of the Lys-X-proteinase of P. gingivalis;
- and
- (ii) part of, or all of a sequence that is the same as, or homologous to the sequence of an adhesin domain of the Arg-X-proteinase of P. gingivalis;
- and
- (iii) part of, or all of a sequence that is the same as, or homologous to the sequence of a HagA adhesin domain of P. gingivalis.
Dependencies are inferred from the claim text.