Compositions and methods for modulating gamma-c-cytokine activity

A pharmaceutical composition comprising:

• a nucleotide sequence encoding a peptide conjugate, or a derivative thereof;
• and
• a pharmaceutically acceptable carrier, diluent, excipient or combination thereof;
• wherein the peptide conjugate or the derivative thereof modulates the activity of two or more γc-cytokines selected from the group consisting of IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21;
• wherein the peptide conjugate or the derivative thereof comprises an amino acid sequence D/E-F-L-E/Q/N-S/R-X-I/K-X-L/I-X-Q (SEQ ID NO:
• 2), wherein X denotes any amino acid.

A genetic construct comprising:

• a nucleotide sequence encoding a composite peptide;
• and
• at least one regulatory element, wherein the at least one regulatory element is configured to regulate an expression of the composite peptide,
• wherein the composite peptide, when expressed, can modulate the activity of two or more γc-cytokines selected from the group consisting of IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21;
• wherein the composite peptide comprises an amino acid sequence D/E-F-L-E/Q/N-S/R-X-I/K-X-L/I-X-Q (SEQ ID NO:
• 2), wherein X denotes any amino acid.