Organometallic Antibiotics
OwnerIan Michael Hendersoninventor
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Abstract
The present invention discloses a class of antibiotics designed to target non-protein transporters. Further, a method is described to treat infections by targeted binding of a lipid transporter utilizing organometallic compounds, coordination compounds, metal centers, or any combination thereof. The antibiotics described herein are designed to halt or negatively affect the reproduction of bacteria by disrupting the biosynthesis of the cell wall and other important bacterial compounds such as lipopolysaccharide and techoic acids.
Claims13
A chemical compound having the formula:
- wherein R1 is a hydrophobic group comprising an aryl, alkyl, or flouoalkyl moiety;
- wherein R2 and R3, which are the same or different and are hydrogen, halogen, CR3, CF3, or part of an aromatic ring;
- wherein R4 is a chemical group capable of binding a phosphate or pyrophosphate, comprising hydrogen bond donors, groups bearing a positive charge, or groups capable of phosphate and/or pyrophosphate binding;
- wherein x and y are the same or different and are 0-6;
- wherein M is a metal selected from Pt, Pd, or Ni, having oxidation states from 0 to (IV);
- wherein L1 and L2 are the same or different and are selected from alkenes or phosphines.
A method of treating infections, broadly defined, via targeted binding of a lipid transporter utilizing organometallic compounds, coordination compounds, metal centers, or any combination thereof.
A method of treating infections, broadly defined, via targeted binding of isoprenoid phosphates, and isoprenoid and/or terpenoid compounds other than pyrophosphate derivatives and isoprenoid-based lipids containing a pyrophosphate linker.
Dependencies are inferred from the claim text.