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US 2019/0194228 A1Published application
NEW 1,2,4-TRIAZOLO-[3,4-b]-1,3,4-THIADIAZOLE DERIVATIVES
AssigneesGalenica AB, Energonbio Technologies S.A.
InventorDimitrios TRAFALIS
Life of this patent
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Abstract
Derivatives of 1,2,4-Triazolo-[3,4-b]-1,3,4-thiadiazoles according to formula (I), as set forth below: processes for production thereof, pharmaceutical compositions containing the same and the use thereof in treatment of cancer.
Claims15
A compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein
- R1 and R2 are the same or different and are selected from the group consisting of C1-C5 alkyl, phenyl, methylphenyl,
- R3 is selected from the group consisting of
- CH2R8, CH2CH2R3, CH═CHR8, CH2CH2CH2R8, CH2CH═CHR8, CH═CHCH2R8, CH═CH—OR8, CH2—OR8, CH2CH2—OR8, CH═CH—NHR8, CH2—NHRs, CH2CH2—NHR8, CH═CH—SR8, CH2—SR8, CH2CH2—SR8,
- substituted or unsubstituted phenyl, benzyl, pyridyl, pyrirnidinyl, triazinyi, triazinanyl, oxazinyl, oxazinanyl, cycloexanyl, cycloexenyl, cycloexadienyl, pyranyl, oxathianyl, piperidinyl, cyclopentanyl, cyclopentenyl, cyclopentadienyl, pyrrolidinyl, pyrrolyl, furanyl, oxazolidinyl, pyrazolidinyl, thiophenyl, oxathilnyl, oxathiolyl, oxathiolanyl, wherein the substituent or substituents are selected from the group consisting of rnethyl, F, Cl, Br, I, NO2, ON, NH2, OCH2X, CH2X, CX3, CH2CH2X, OH, wherein X is selected from the group consisting of H, F, Cl, Br, I,
- R4, R5, R6, R7 are the same or different and selected from the group consisting of:
- H, F, Cl, Br, I, NO2, ON, NH2, OCH3, OH, NHCH2CH3, N(CH3)2,
- R8 is selected from the group consisting of:
- substituted or unsubstituted phenyl, benzyl, pyridyl, pyrimidinyl, triazinyl, triazinanyi, oxazinyl, oxazinanyl, cycloexanyl, cycloexenyl, cycloexadienyl, pyranyl, oxathianyl, piperidinyl, cyclopentanyl, cyclopentenyl, cyclopentadienyl, pyrrolidinyl, pyrrolyl, furanyl, oxazolidinyl, pyrazolidinyl, thiophenyl, oxathiinyl, oxathiolyi, oxathiolanyl, wherein the substituent or substituents are selected from the group consisting of:
- methyl, F, Cl, Br, I, NO2, ON, NH2, OCH2X, CH2X, CX3, CH2CH2X, OH, wherein X is selected from the group consisting of H, F, Cl, Br, I,
- R9 is selected from the group consisting of:
- NHR10, NR11R12,
- R10 is selected from the group consisting of:
- C1-C5 alkyl, phenyl,
- R11 and R12 are the same or different and are C1-C5 alkyl.
12 more elements
Dependencies are inferred from the claim text.