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US 2019/0194227 A1Published application
Bmp potentiators
AssigneeNovartis AG
InventorsJian DING, Marie-Helene LARRAUFIE, Deborah ROTHMAN, Nik SAVAGE, Shaowen WANG
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Abstract
The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.
Claims16
A method of potentiating bone morphogenetic protein (BMP) signaling in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein:
- each R1 is independently selected from the group consisting of halo, cyano, C1-6 alkyl, C1-6 alkoxyl, C2-6 alkenyl, C2-6 alkynyl, heteroC1-10 alkyl, and C1-6 haloalkyl;
- n is 1, 2, 3, 4, or 5;
- and
- m is 0, 1, 2, 3, or 4.
1 more element
A method of treating a disease or disorder in a subject in need thereof selected from the group consisting of:
- PAH (pulmonary arteria hypertension);
- HHT (hereditary hemorrhagic telangiectasia);
- iron overload anemia;
- fracture healing;
- macular degeneration;
- glaucoma;
- dry eye;
- colitis;
- IBD (inflammatory bowel disease);
- juvenile polyposis syndrome;
- and fibrosis, the method comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein:
- each R1 is independently selected from the group consisting of halo, cyano, C1-6 alkyl, C1-6 alkoxyl, C2-6 alkenyl, C2-6 alkynyl, heteroC1-10 alkyl, and C1-6 haloalkyl;
- n is 1, 2, 3, 4, or 5;
- and
- m is 0, 1, 2, 3, or 4.
12 more elements
Dependencies are inferred from the claim text.