Dopamine d3 receptor antagonists having a bicyclo moiety

A compound, or a pharmaceutically acceptable salt thereof, having the formula:

• wherein;
• A is a saturated 4-6 carbocyclic ring, optionally in which one or two carbon atoms is heteroatoms selected among nitrogen and oxygen;
• and in which the group G is linked to a carbon or nitrogen;
• such ring may optionally be substituted at the carbon atoms or nitrogen atom by one or more C1-4alkyl groups;
• B is a saturated 4-6 heterocyclic ring in which one or two carbon atoms is heteroatoms selected among Nitrogen or Oxygen and the linking atom is always a Nitrogen atom;
• such ring may be also substituted at the carbon atoms or, possibly, at the different Nitrogen atom, by one or more C1-4alkyl group;
• G is phenyl, or a 5-6 membered heteroaromatic group, which is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of:
• halogen, cyano, hydroxyl, amino, C1-4alkylamino, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy, SF5, —C(═O)NH2, —C(═O)OR3;
• W is S, SO2, O, CHR2, NR3;
• n is 0 or 1;
• m is 1 or 2;
• p is 1 or 2;
• z is 0 or 1;
• R is hydrogen, C1-4alkyl;
• C1-4alkoxy;
• R1 is hydrogen, F, C1-4alkyl;
• hydroxyl, C1-4alkoxy;
• R2 is hydrogen, F, C1-4alkyl;
• hydroxyl, C1-4alkoxy;
• R3 is hydrogen, C1-4alkyl;
• R4 is hydrogen or C1-4alkyl;
• or —C(═O)C1-4alkyl;
• —C(═O)C1-4alkoxyC1-4alkyl;
• —C(═O)cyclopropyl;
• R5 is hydrogen, C1-4alkyl;
• R6 is hydrogen, C1-4alkyl;
• R7 is halogen, C1-4alkyl;
• hydroxyl, C1-4alkoxy;
• G1 is phenyl or a 5-6-membered heteroaromatic group or a 8-11 membered heteroaromatic group;
• any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of:
• halogen, cyano, hydroxyl, amino, C1-4alkylamino, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, SF5, —C(═O)NH2, —C(═O)(O)zR3;
• Y is phenyl or a moiety selected from the group consisting of:
• 5-6 membered heteroaromatic group, a 8-11 membered heteroaromatic group;
• a saturated mono 3-7 membered carbocyclic group or a 8-11 membered bicyclic carbocyclic group in which one or more atom carbons may be replaced by N(R4)z, O, S;
• any of such groups may be optionally substituted by 1, 2 or 3 substituents selected from:
• halogen, cyano, hydroxyl, C1-4alkylamino, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl, —C(═O),—NHR4, —NR5R6, SF5, —C(═O)zR3, —═O, and (CH2)zC(═O)N(R4R5);
• when G1 is a phenyl group, then G1 and Y may be fused together to form a benzofused aromatic or heteroaromatic system which might be optionally substituted by one or two substituents selected from:
• halogen, cyano, hydroxy, amino C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl, —C(═O)NH2, —C(═O)OR3, and SF5.