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US 2019/0194224 A1Published application
Bacterial topoisomerase i inhibitors with antibacterial activity
AssigneesThe Florida International University Board of Trustees, University of Hawaii
InventorsYuk-Ching TSE-DINH, Dianqing SUN
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Abstract
The present invention provides compounds as bacterial topoisomerase inhibitors with antibacterial activity. The present invention also provides pharmaceutical compositions comprising at least one of the compounds and methods of using the compounds and pharmaceutical compositions as antibacterial agents for treating infectious diseases,
Claims20
A compound having the following structure:
- R1 being selected from —OH, —NH2, —NO2, —NHMe, —Ac, —CN, —NHAc, —NHCH2CH2NH2, —CF3, fluorine, chloride, bromine, iodine, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, heterocycloalkyl, and substituted heterocycloalkyl;
- R2 being selected from H, alkyl, and substituted alkyl;
- R3 being F;
- and
- R4 being selected from fluorine, chloride, bromine, and iodine.
2 more elements
A compound having the following structure:
- R1 being selected from —NH2, —NO2, —Ac, —CN, —NHAc, and —CF3;
- R2 being selected from H, alkyl, and substituted alkyl;
- R3 being selected from fluorine, chloride, bromine, iodine, amino,
- R4 being H, fluorine, chloride, bromine or iodine;
- and
- R5 being H, —NH2, —NO2 or —NHBoc.
3 more elements
Dependencies are inferred from the claim text.