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US 2019/0194223 A1Published application
THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS
AssigneeGilead Sciences, Inc.
InventorsMichael O' Neil Hanrahan Clarke, Richard L. Mackman, Dustin Siegel
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Abstract
Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds.
Claims23
1-4. (canceled)
A compound of Formula (II):
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is selected from the group consisting of H, CH3, F, Cl, and NH2;
- R2 is selected from the group consisting of F, Cl, OH, NH2, CN, and N3;
- R3 is selected from the group consisting of CN, N3, methyl, ethyl, propyl, vinyl, propenyl, ethynyl, CH2F, CHF2, CH2Cl, CH2SMe, and CH2OMe;
- and
- R4 is selected from the group consisting of H,
- wherein
- R8 is phenyl,
- R9 is H or CH3;
- R10 is H or C1-C6 alkyl;
- and
- R11 is H or C1-C8 alkyl.
9 more elements
(canceled)
26-28. (canceled)
Dependencies are inferred from the claim text.