New use of triazolo(4,5 d)pyrimidine derivatives for prevention and treatment of bacterial infection
AssigneeUniversite De Liege
InventorsCécile Oury, Patrizio Lancellotti
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Abstract
Triazolo(4,5-d)pyrimidine derivatives for use in treatment or prevention of bacterial infection in a host mammal in need of such treatment or use as inhibitor of biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers.
Claims23
A Triazolo(4,5-d)pyrimidine derivative of formula (I):
- wherein R1 is C3-5 alkyl optionally substituted by one or more halogen atoms;
- R2 is a phenyl group, optionally substituted by one or more halogen atoms;
- R3 and R4 are both hydroxyl;
- R is XOH, wherein X is CH2, OCH2CH2, or a bond;
- or a pharmaceutical acceptable salt or solvate thereof, or a solvate of such a salt provided that when X is CH2 or a bond, R1 is not propyl;
- when X is CH2 and R1 is CH2CH2CF3, butyl or pentyl, the phenyl group at R2 must be substituted by fluorine;
- when X is OCH2CH2 and R1 is propyl, the phenyl group at R2 must be substituted by fluorine.
-14. (canceled)
The method of treatment according to claim 14, wherein an effective amount to be administered to the host is inferior to 1.8 g per day.
A method of bacteria killing or prevention of bacterial growth in biofilm formation comprising using, by applying on a surface, an effective amount of Triazolo(4,5-d)pyrimidine derivative of formula (l) according to claim 8
Dependencies are inferred from the claim text.