Compounds For Reducing c-Myc In c-Myc Overexpressing Cancers Background

A compound according to Formula I or Formula II:

• or, tautomer, a pharmaceutically acceptable ester thereof, prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein
• R is H or any one of groups A-G:
• and wherein
• represents a single or double bond;
• R1, R2, and R3 are N;
• R4 is each independently substituted alkyl, unsubstituted alkyl, substituted alkenyl, unsubstituted alkenyl, substituted alkynyl, unsubstituted alkynyl, aminoalkyl, aminodialkyl, or halogen;
• R5 is each independently substituted alkyl, unsubstituted alkyl, substituted alkenyl, unsubstituted alkenyl, substituted alkynyl, unsubstituted alkynyl, or halogen;
• R6 is substituted C1-10alkyl or unsubstituted C1-10alkyl;
• R7 is H or a group selected from any one of groups J, K and H
• and
• R8 is each independently substituted alkyl, unsubstituted alkyl, substituted O-alkyl, unsubstituted O-alkyl or halogen;
• n for R4 and when R1 is not N, is 0, 1, 2, 3 or 4;
• n for R4 and when R1 is N, is 0, 1, 2 or 3;
• n for R5 iS 0, 1, 2, 3, 4 or 5;
• and
• n for R8 is 0, 1, 2, 3, 4 or 5.

A compound according to Formula I or Formula II:

• or, tautomer, a pharmaceutically acceptable ester thereof, prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein
• R is H or any one of groups A-G:
• and wherein
• represents a single or double bond;
• R1 is CH, substituted C or N;
• R2
• in the compound of Formula I is CH, substituted C or N;
• in the compound of Formula II is O, CH2, substituted C, NH or substituted N;
• R3
• in the compound of Formula I is CH, substituted C or N;
• in the compound of Formula II is
• CH, substituted C or N when represents a single bond;
• or
• C when represents a double bond;
• R4 is each independently aminoalkyl or aminodialkyl, and optionally halogen;
• R5 is each independently substituted alkyl, unsubstituted alkyl, substituted alkenyl, unsubstituted alkenyl, substituted alkynyl, unsubstituted alkynyl, or halogen;
• R6 is substituted C1-10alkyl or unsubstituted C1-10alkyl;
• R7 is H or a group selected from any one of groups J, K and H
• and
• R8 is each independently substituted alkyl, unsubstituted alkyl, substituted O-alkyl, unsubstituted O-alkyl or halogen;
• n for R4 and when R1 is not N, is 0, 1, 2, 3 or 4;
• n for R4 and when R1 is N, is 0, 1, 2 or 3;
• n for R5 iS 0, 1, 2, 3, 4 or 5;
• and
• n for R8 is 0, 1, 2, 3, 4 or 5.