Process for preparing beta 3 agonists and intermediates
AssigneeMerck Sharp & Dohme Corp.
InventorsFeng Xu, Zhuqing Liu, Richard Desmond, Jeonghan Park, Alexei Kalinin, Birgit Kosjek, Hallena Strotman, Hongmei Li, Johannah Moncecchi
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Abstract
The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
Claims8
1-18. (canceled)
A crystalline form of the HCl salt of Compound I-5(b), wherein Compound I-5(b) has the chemical structure:
- and wherein the crystalline form is characterized by an XRPD pattern having 2θ peaks at about 8.6°, 13.5°, and 16.7°.
Dependencies are inferred from the claim text.