Pyrazole carboxamide compounds and methods of use

A compound selected from Formula I:

• or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein:
• X is CH
• R1, R2 and R3 are independently selected from H, —C(O)NH2, C6-C20 aryl, C3-C12 carbocyclyl, C2-C20 heterocyclyl, C1-C20 heteroaryl, —NH2, —NH—(C6-C20 aryl), —NH—(C1-C20 heteroaryl), —C(O)—(C1-C12 alkyl), —C(O)—(C3-C12 carbocyclyl), —NH—(C1-C12 alkylene)-(C2-C20 heterocyclyl), —NH—(C1-C20 heteroaryl)-(C2-C20 heterocyclyl), —NHC(O)—(C3-C12 carbocyclyl), —NHC(O)—(C1-C12 alkyl), —(C6-C20 aryl)-C(O)—(C2-C20 heterocyclyl), and —(C1-C20 heteroaryl)-(C2-C20 heterocyclyl);
• at least one of R1, R2 and R3 is —C(O)NH2;
• R4 is selected from H, F, Cl, CN, —CH2OH, —CH(CH3)OH, —C(CH3)2OH, —CH(CF3)OH, —CH2F, —CHF2, —CH2CHF2, —CF3, —C(O)NH2, —C(O)NHCH3, —C(O)N(CH3)2, —NH2, —NHCH3, —N(CH3)2, —NHC(O)CH3, —OH, —OCH3, —OCH2CH3, —OCH2CH2OH, cyclopropyl, cyclopropylmethyl, 1-hydroxycyclopropyl, imidazolyl, pyrazolyl, 3-hydroxy-oxetan-3-yl, oxetan-3-yl, and azetidin-1-yl;
• R5 is H, F, Cl, or CN;
• R6 is selected from the structures:
• where the wavy line indicates the site of attachment;
• and
• alkyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, —CN, —CH3, —CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2NH2, —CH2NHCH3, —CH2N(CH3)2, —CH2OH, —CH2OCH3, —CH2CH2OH, —C(CH3)2OH, —CH(OH)CH(CH3)2, —C(CH3)2CH2OH, —CH2CH2SO2CH3, —CH2OP(O)(OH)2, —CH2F, —CHF2, —CF3, —CH2CF3, —CH2CHF2, —CH(CH3)CN, —C(CH3)2CN, —CH2CN, —CO2H, —COCH3, —CO2CH3, —CO2C(CH3)3, —COCH(OH)CH3, —CONH2, —CONHCH3, —CON(CH3)2, —CONH(CH2CH2N(CH3)2), —C(CH3)2CONH2, —NH2, —NHCH3, —N(CH3)2, —NHCOCH3, —N(CH3)COCH3, —NHS(O)2CH3, —N(CH3)C(CH3)2CONH2, —N(CH3)CH2CH2S(O)2CH3, —NO2, ═O, —OH, —OCH3, —OCH2CH3, —OCH2CH2OCH3, —OCH2CH2OH, —OCH2CH2N(CH3)2, —OP(O)(OH)2, —S(O)2N(CH3)2, —SCH3, —S(O)2CH3, —S(O)3H, cyclopropyl, oxetanyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-yl amino, azetidin-1-ylmethyl, pyrrolidin-1-yl, and morpholino.