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US 2019/0194193 A1Published application
Aminoquinazoline compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity
AssigneeWellstat Therapeutics Corporation
InventorsDavid M. SIMPSON, Dennis Bryan ZERBY, Ming LU, Reid W. VON BORSTEL, Rui LI, Julian READING, Stephen WOLPE
Life of this patent
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Abstract
Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.
Claims22
A compound represented by Formula IB1 or a pharmaceutically acceptable salt thereof
- wherein n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
- Q is absent or present and is O or NHC(O), provided that if Q is present n cannot be 0 or 1;
- R1 is hydrogen or halo;
- and
- R7 is selected from the group consisting of:
- hydrogen,
- alkyl having from 1 to 6 carbon atoms;
- and
- phenyl or monocyclic aromatic ring having one nitrogen atom, unsubstituted or substituted by alkyl having from 1 to 6 carbon atoms or alkoxy having from 1 to 10 carbon atoms or phenyl or phenoxy;
- provided that if Q is absent, then (CH2)nR7 must have more than 5 carbon atoms.
7 more elements
A compound, N-(Decyl)quinazolin-4-amine or a pharmaceutically acceptable salt thereof.
13-19. (canceled)
28-34. (canceled)
Dependencies are inferred from the claim text.