Novel benzylamino substituted pyridopyrimidinones and derivatives as sos1 inhibitors

A compound of formula (I)

• wherein
• R1 is Ra1;
• Ra1 is selected from the group consisting of C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C4-10locycloalkenyl, 3-10 membered heterocyclyl, C6-10aryl and 5-10 membered heteroaryl, wherein the C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C4-10cycloalkenyl, 3-10 membered heterocyclyl, C6-10aryl and 5-10 membered heteroaryl are all optionally substituted by one or more, identical or different Rb1 and/or Rc1;
• each Rb1 is independently selected from the group consisting of —ORc1, —NRc1Rc1, halogen, —CN, —C(O)Rc1, —C(O)ORc1, —C(O)NRc1Rc1, —S(O)2Rc1, —S(O)2NRc1Rc1, —NHC(O)Rc1, —N(C1-4alkyl)C(O)Rc1, —NHC(O)ORc1 and —N(C1-4alkyl)C(O)ORc1;
• each Rc1 is independently selected from the group consisting of hydrogen, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C4-10cycloalkenyl, 3-10 membered heterocyclyl, C6-10aryl and 5-10 membered heteroaryl, wherein the C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C4-10cycloalkenyl, 3-10 membered heterocyclyl, C6-10aryl and 5-10 membered heteroaryl are all optionally substituted by one or more, identical or different Rd1 and/or Re1;
• each Rd1 is independently selected from the group consisting of —ORe1, —NRe1Re1, halogen, —CN, —C(O)Re1, —C(O)ORe1, —C(O)NRe1Re1, —S(O)2Re1, —S(O)2NRe1Re1, —NHC(O)Re1, —N(C1-4alkyl)C(O)Re1, —NHC(O)ORe1 and —N(C1-4alkyl)C(O)ORe1;
• each Re1 is independently selected from the group consisting of hydrogen, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C4-10cycloalkenyl, 3-10 membered heterocyclyl, C6-10aryl and 5-10 membered heteroaryl;
• R2 is selected from the group consisting of hydrogen, C1-4alkyl, C3-6cycloalkyl, 3-6 membered heterocyclyl and halogen;
• R3 is selected from the group consisting of hydrogen, C1-4alkyl and C1-4haloalkyl;
• ring system A is selected from the group consisting of C6-10aryl, 5-10 membered heteroaryl and 9-10 membered bicyclic heterocyclyl;
• p denotes 1, 2 or 3;
• each R4 is independently selected from the group consisting of C1-4alkyl, C2-4alkenyl, C2-4alkinyl, C1-4haloalkyl, hydroxy-C1-4alkyl, hydroxy-C1-4haloalkyl, C3-6cycloalkyl, 3-6 membered heterocyclyl, hydroxy-C3-6cycloalkyl, C1-4haloalkyl substituted with a 3-6 membered heterocyclyl, 3-6 membered heterocyclyl substituted with hydroxy, halogen, —NH2, —SO2—C1-4alkyl and the bivalent substituent ═O, while ═O may only be a substituent in a non-aromatic ring;
• or a salt thereof.