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US 2019/0194186 A1Published application
HETEROARYL SUBSTITUTED BENZOIC ACIDS AS RORgammaT INHIBITORS AND USES THEREOF
AssigneeMerck Sharp & Dohme Corp.
InventorsHongjun Zhang, Kenneth Jay Barr, Blair T. Lapointe, Hakan Gunaydin, Kun Liu, B. Wesley Trotter
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Abstract
The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.
Claims28
A compound according to Formula I:
- wherein:
- X is CH or N;
- n is 0, 1 or 2;
- R1 is independently OH, halo or (C1-4)alkyl;
- R2 is independently OH, halo, (C1-4)alkyl, CH2F, CHF2 or CF3;
- and
- R3 is CH2F, CHF2 or CF3;
- or a pharmaceutically acceptable salt thereof.
5 more elements
A compound selected from:
- 3-fluoro-4-(1-(2-methyl-6-(1-(trifluoromethyl)cyclopropyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoic acid;
- 4-(1-(2-chloro-6-(1-(difluoromethyl)cyclopropyl) benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid;
- 4-(1-(2-chloro-6-(1-(trifluoromethyl)cyclopropyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid;
- 4-(1-(2-chloro-3-fluoro-6-(1-(trifluoromethyl)cyclopropyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid;
- 4-(1-(2-(difluoromethyl)-6-(1-(trifluoromethyl)cyclopropyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid;
- 4-(1-(2-chloro-6-(1-(difluoromethyl)cyclopropyl)-3-fluorobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid;
- 3-fluoro-4-(1-(3-fluoro-2-methyl-6-(1-(trifluoromethyl)cyclopropyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)benzoic acid;
- and
- 4-(1-(2-chloro-6-(1-(trifluoromethyl)cyclopropyl)benzoyl)-1H-pyrrolo[3,2-b]pyridin-3-yl)-3-fluorobenzoic acid;
- or a pharmaceutically acceptable salt thereof.
7 more elements
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A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.