Inhibitors of jun n-terminal kinase

A compound having a structure according to Formula (I):

• or a salt or solvate thereof,
• wherein
• ring A is 5-membered heteroaryl comprising a sulfur atom, wherein the heteroaryl is optionally substituted with 1 or 2 substituents independently chosen from alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, C3-C10-cycloalkyl, 3- to 8-membered heterocycloalkyl, aryl, 5- or 6-membered heteroaryl, CN, halogen, OR12, SR12, NR12R13, C(O)R14, C(O)NR12R13, OC(O)NR12R13, C(O)OR12, NR15C(O)R14, NR15C(O)OR12, NR15C(O)NR12R13, NR15C(S)NR12R13, NR15S(O)2R14, S(O)2NR12R13, S(O)R14 and S(O)2R14,
• wherein
• R12, R13 and R15 are independently chosen from H, acyl, C1-C6-alkyl, 2- to 6-membered heteroalkyl, aryl, 5- or 6-membered heteroaryl, C3-C8 cycloalkyl and 3- to 8-membered heterocycloalkyl, or R12 and R13, together with the nitrogen atom to which they are bound form a 5- to 7-membered heterocyclic ring;
• and
• R14 is chosen from acyl, C1-C6-alkyl, 2- to 6-membered heteroalkyl, aryl, 5- or 6-membered heteroaryl, C3-C8 cycloalkyl and 3- to 8-membered heterocycloalkyl;
• Ca and Cb are carbon atoms, which are adjacent to each other and are part of ring A;
• Z is 5- or 6-membered heteroaryl, with the proviso that
• (i) when ring A is thiophene, then Z is not a heteroaryl chosen from benzoimidazole, thiazole, and benzothiazole;
• (ii) when ring A is thiazole, then Z is not benzoimidazole;
• (iii) when ring A is thiophene, then Z is not substituted oxadiazole;
• and
• (iv) when ring A is thiophene, then Z is not pyrimidinone;
• R5 is chosen from H, acyl, C1-C6 alkyl, and C3-C6 cycloalkyl;
• W is chosen from C1-C4 alkylene, wherein the alkylene is optionally substituted with 1-4 substituents independently chosen from alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, C3-C6-cycloalkyl, 3- to 8-membered heterocycloalkyl, aryl, 5- or 6-membered heteroaryl, CN, halogen, OR42, SR42, NR42R43, C(O)R44, C(O)NR42R43, OC(O)NR42R43, C(O)OR42, NR45C(O)R44, NR45C(O)OR42, NR45C(O)NR42R43, NR45C(S)NR42R43, NR45S(O)2R44, S(O)2NR42R43, S(O)R44, and S(O)2R44,
• wherein
• R42, R43 and R45 are members independently chosen from H, acyl, C1-C6-alkyl, 2- to 6-membered heteroalkyl, aryl, 5- or 6-membered heteroaryl, C3-C8 cycloalkyl and 3- to 8-membered heterocycloalkyl, wherein R42 and R43, together with the nitrogen atom to which they are bound are optionally joined to form a 5- to 7-membered heterocyclic ring;
• and
• R44 is independently chosen from acyl, C1-C6-alkyl, 2- to 6-membered heteroalkyl, aryl, 5- or 6-membered heteroaryl, C3-C8 cycloalkyl and 3- to 8-membered heterocycloalkyl;
• Cy is chosen from cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, wherein the cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with 1-6 substituents independently chosen from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, haloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, CN, halogen, OR52, SR52, NR52R53, C(O)R54, C(O)NR52R53, OC(O)NR52R53, C(O)OR52, NR55C(O)R54, NR55C(O)OR52, NR55C(O)NR52R53, NR55C(S)NR52R53, NR55S(O)2R54, S(O)2NR52R53, S(O)R54 and S(O)2R54,
• wherein
• R52, R53 and R55 are independently chosen from H, acyl, C1-C6-alkyl, 2- to 6-membered heteroalkyl, aryl, 5- or 6-membered heteroaryl, C3-C8 cycloalkyl and 3- to 8-membered heterocycloalkyl, wherein R52 and R53, together with the nitrogen atom to which they are bound are optionally joined to form a 5- to 7-membered heterocyclic ring;
• and
• R54 is independently chosen from acyl, C1-C6-alkyl, 2- to 6-membered heteroalkyl, aryl, 5- or 6-membered heteroaryl, C3-C8 cycloalkyl and 3- to 8-membered heterocycloalkyl.