6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1h)-one as apj agonists

A compound of Formula (I):

• or a stereoisomer, an enantiomer, a diastereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein
• ring A is independently selected from C3-6 cycloalkyl, —(CH2)0-1-5- or 6-membered aryl and heterocyclyl comprising carbon atoms and 1-4 heteroatoms selected from N, NR3a, O, and S, each substituted with 1-3 R3 and 1-2 R5;
• provided R3 and R5 are not both H;
• ring B is independently selected from C3-6 cycloalkyl, C3-6 cycloalkenyl, aryl, bicyclic carbocyclyl, 6-membered heteroaryl, 6-membered heterocyclyl, and bicyclic heterocyclyl, each substituted with 1-3 R1;
• R1 is independently selected from H, F, Cl, Br, NO2, —(CH2)nORb, (CH2)nS(O)pRc, —(CH2)nC(═O)Rb, —(CH2)nNRaRa, —(CH2)nCN, —(CH2)nC(═O)NRaRa, —(CH2)nNRaC(═O)Rb, —(CH2)nNRaC(═O)NRaRa, —(CH2)nNRaC(═O)ORb, —(CH2)nOC(═O)NRaRa, —(CH2)nC(═O)ORb, —(CH2)nS(O)pNRaRa, —(CH2)nNRaS(O)pNRaRa, —(CH2)nNRaS(O)pRc, C1-4 alkyl substituted with 0-3 Re, —(CH2)n—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)n-heterocyclyl substituted with 0-3 Re;
• R2 is independently selected from C1-5 alkyl substituted with 0-3 Re;
• C2-5 alkenyl substituted with 0-3 Re, aryl substituted with 0-3 Re, heterocyclyl substituted with 0-3 Re, and C3-6 cycloalkyl substituted with 0-3 Re;
• provided when R2 is C1-5 alkyl, the carbon atom except the one attached to the pyrimidine ring may be replaced by O, N, and S;
• R3 is independently selected from H, F, Cl, Br, C1-5 alkyl substituted with 0-3 Re, —(CH2)nORb, —(CH2)nNRaRa, —(CH2)nCN, —(CH2)nC(═O)Rb, —(CH2)nC(═O)ORb, —(CH2)nC(═O)NRaRa, —(CH2)nNHC(═O)Rb, —(CH2)nNHC(═O)NRaRa, —(CH2)nNHC(═O)ORb, —(CH2)nNHS(O)pNRaRa, —(CH2)nNHS(O)pRc —(CH2)nS(O)pRc, —(CH2)nS(O)pNRaRa, and —(CH2)nOC(═O)NRaRa;
• R3a is independently selected from H, C1-5 alkyl substituted with 0-3 Re, —S(O)pRc, —C(═O)Rb, —C(═O)NRaRa, —C(═O)ORb, S(O)pNRaRa, R6, —S(O)pR6, —C(═O)R6, —C(═O)NRaR6, —C(═O)OR6, and —S(O)pNRaR6;
• R4 is independently selected from H, C1-5 alkyl substituted with 0-3 Re, C2-5 alkenyl substituted with 0-3 Re, (CH2)n—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)n-heterocyclyl substituted with 0-3 Re;
• R5 is independently selected from H, R6, —OR6, —S(O)pR6, —C(═O)R6, —C(═O)OR6, —NRaR6, —C(═O)NRaR6, —NRaC(═O)R6, —NRaC(═O)OR6, —OC(═O)NRaR6, —S(O)pNRaR6, —NRaS(O)pNRaR6, and —NRaS(O)pR6;
• R6 is independently selected from —(CR7R7)n-aryl, —(CR7R7)n—C3-6 cycloalkyl, and —(CR7R7)n-heteroaryl, each substituted with 1-6 R8;
• R7 is independently selected from H, C1-4 alkyl, and (CH2)n—C3-12 carbocyclyl substituted with 0-3 Re;
• R8 is independently selected from H, F, Cl, Br, —(CH2)nCN, —(CH2)nORb, —(CH2)nC(═O)Rb, —(CH2)nC(═O)ORb, —(CH2)nC(═O)NRaRa, —(CH2)nNRaRa, —(CH2)nNRaC(═O)Rb, —(CH2)nNRaC(═O)ORb, —(CH2)nNRaC(═O)NRaRa, —(CH2)nOC(═O)NRaRa, —(CH2)nS(O)pRc, —(CH2)nS(O)pNRaRa, —(CH2)nNRaS(O)pNRaRa, —(CH2)nNRaS(O)pRc, C1-4 alkyl substituted with 0-3 Re, (CH2)n—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)n-heterocyclyl substituted with 0-3 Re;
• Ra is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)n—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)n-heterocyclyl substituted with 0-5 Re;
• or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 Re;
• Rb is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)n—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)n-heterocyclyl substituted with 0-5 Re;
• Rc is independently selected from C1-6 alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6alkynyl substituted with 0-5 Re, C3-6carbocyclyl, and heterocyclyl;
• Re is independently selected from C1-6 alkyl substituted with 0-5 Rf, C2-6 alkenyl, C2-6 alkynyl, —(CH2)n—C3-6 cycloalkyl, —(CH2)n—C4-6 heterocyclyl, —(CH2)n-aryl, —(CH2)n-heteroaryl, F, Cl, Br, CN, NO2, ═O, CO2H, —(CH2)nORf, S(O)pRf, C(═O)NRfRf, NRfC(═O)Rf, S(O)pNRfRf, NRfS(O)pRf, NRfC(═O)ORf, OC(═O)NRfRf, and —(CH2)nNRfRf;
• Rf is independently selected from H, F, Cl, Br, CN, OH, C1-5alkyl (optimally substituted with F, Cl, Br and OH), C3-6 cycloalkyl, and phenyl, or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C1-4alkyl;
• n is independently selected from zero, 1, 2, 3, and 4;
• and
• p is independently selected from zero, 1, and 2.